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giving a prevalence of pathogenic MC4R mutations of 1.4% ( n = 32/2,291) in adults with obesity in the SURMOUNT-1 study (Extended Data Table 1)

And Phase 2 trials typically use smaller, less optimized populations than Phase 3 trials

Consider tracking protein intake specifically during the first 3 months of treatment when appetite suppression is most severe

Clinical results and weight loss outcomes Numbers tell the story better than marketing copy ever could

This can be challenging on tirzepatide because the appetite suppression makes eating difficult

Lingvay I, Sumithran P, Cohen RV, le Roux CW
