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The standard Wegovy protocol produces roughly 35 pounds of weight loss over 16 months

Some patients with specific FTO or GIPR variants may benefit from more gradual dose escalation or combination approaches (like GLP-Squared, which pairs semaglutide and tirzepatide) to minimize digestive disruption

Best suited for patients with a 1015% weight loss goal or those for whom tirzepatide isn't the right clinical fit

And these might also be confounding factors when I think about it, since patients with these Ed prone conditions are more likely than to use GLP-1 agonists

These serious side effects can occur with Wegovy

doi: 10.3389/fnagi.2020.580609, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Mazzo F., Butnaru I., Grubisha O., Ficulle E., Sanger H., Fitzgerald G., et al