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It causes upper abdominal pain, bloating, early fullness, nausea, and vomiting, and is managed through optimising blood glucose control, eating smaller frequent meals with reduced fat content, and sometimes using prokinetic medications under specialist supervision

Many individuals experience mild gastrointestinal side effects like nausea or stomach discomfort, especially in the day or two following an injection

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Published studies with metformin use during pregnancy have not reported a clear association with metformin and major birth defect or miscarriage risk [see Data]

Cet article a initialement paru sur le site nationalgeographic.com en langue anglaise.

doi: 10.1016/0014-5793(94)00553-2