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WHO Expert Consultation

There are several types of GLP medications that engage different types of glucagon receptors, giving them different effects in different people: Single receptor agonists (GLP-1 only): Ozempic, Wegovy, Saxenda Dual receptor agonists (GLP-1 + GIP): Mounjaro, Zepbound Triple receptor agonists (GLP-1 + GIP + glucagon): in development early studies show even greater metabolic effects These medications are changing how we are able to ameliorate obesity, food addiction, insulin resistance, and cardiometabolic risks

Despite these advances, several controversies remain unresolved

Dulaglutide: Brand name Trulicity FDA approved for Type 2 Diabetes Mellitus (T2DM) and requires a PA with chart notes documenting diagnosis (confirmed with lab values) and trial and failure with 30 days of metformin or another antidiabetic drug

The specific macronutrient composition of the increased calories consumed in the luteal phase varies, but most often results from either increased fat (35, 38) or carbohydrate intake (35, 36, 38)