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The landmark STEP trials documented an average weight loss of 15% of starting body weight over 68 weeks at the highest dose, compared to 2-3% with placebo
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Hypoxia-inducible factor 1 alpha (HIF-1) is a vital transcription factor regulated by reduced oxygen levels
doi:10.1001/jamainternmed.2013.2720 57
However, these results may be due to weight loss rather than to the GLP-1RA medication sepecifically
