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Related Stories Eight-hour eating window sustains long-term weight loss GLP-1 weight loss may reduce first-impression penalties in relationships and hiring Blood ketone threshold may help predict weight loss success For GLP-1 analog monotherapy patients, the percent TBWL was computed from baseline to six and 12 months

The 2025 Garvey REDEFINE-1 Phase 3 trial published in NEJM provided the head-to-head four-arm comparison combined formulation, semaglutide alone, cagrilintide alone, and placebo demonstrating the additive contribution of the amylin component on top of GLP-1 monotherapy (PMID 40544433)

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There are reports of patients who have increased the dosage of these drugs to many times higher than recommended

Overall safety profile: Meta-analysis found no significant increase in overall adverse events compared to placebo [6][7]