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As governments and insurers recognize the economic and healthcare burden of obesity, coverage and accessibility are set to improve, further accelerating market adoption

Long-term studies have shown that semaglutide GLP-1 remains effective and safe for weight loss over one to two years

In preclinical efficacy studies in diet-induced obese (DIO) mice and obese monkeys, treatment with AMG133 reduces body weight and improves metabolic parameters to a larger extent than a GLP-1 receptor agonist alone (50)

For subjects treated with the highest dose of tirzepatide (15 mg per week), the risk to develop any major adverse cardiovascular event (MACE-4 composed of myocardial infarction, stroke, hospitalization for angina, and all-cause death) was estimated at 050 (026095)

The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test
Nogueiras R, Nauck MA, Tschop MH
