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In AD, along with amyloid and tau phosphorylation, there is an associated increase in inflammation/glial activation, a decrease in synaptic function, an increase in astrocyte activation, and a state of insulin resistance

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For Mounjaro, side effects are similar and dose-dependent [41]

81 The microbiome and immune system engage in bidirectional communication, with dysbiotic microbiota from IBD patients or colitis models shown to exacerbate or induce inflammation when transferred to healthy or susceptible hosts