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The main aim was to achieve a histological response at week 52 defined as 2 points of improvement in NAS score without impairment of fibrosis and a fibrosis regression of at least one stage without impairment of steatohepatitis

PMCID: PMC6484814

Materials and Methods STEP 1 and 4 were phase III, 68week, placebocontrolled trials of onceweekly semaglutide 2.4 mg combined with lifestyle intervention

In muscle cells, creatine forms phosphocreatine, which: Regenerates ATP your cells primary energy source during high-intensity efforts Improves strength and power , allowing you to train harder and lift heavier Supports protein synthesis and reduces markers of muscle breakdown For individuals on GLP-1 medications, creatine can counteract the lean-mass loss by bolstering workout performance and signaling the body to preserve muscle tissue

This relationship is well documented in medical literature and applies to weight loss achieved through any meansdiet, exercise, bariatric surgery, or medication

But, we spoke to someone who took weight-loss medication, and said it changed their life for the better when taken the right way