semaglutide end date Full article: Effects of on one-year medical costs among patients with obesity or overweight in US real world setting Medicare launches weight loss drug

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What they found was cost dominates treatment decisions: 68% said cost influenced their decision to start or continue treatment 44% said the medication cost more than they expected Cost surpassed side effects as the #1 reason people stopped taking GLP-1s A breakdown of the financial burden: 24% pay more than $250 per prescription fill Nearly 8% pay $500 or more per fill 24% said insurance didn't cover any cost Weight management patients were nearly twice as likely to pay $250+ vs diabetes patients --- Here's what patients are thinking: Nearly 40% ended up using discount programs or manufacturer coupons 60% know someone who wants GLP-1s but can't afford them 83% believe Americans turn to DTC programs because traditional healthcare is too expensive Patients still prioritize safety: 60% are aware of safety risks with non-FDA-approved GLP-1s--this one surprised me

While newly approved pharmacotherapies such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) show efficacy, their clinical utility remains constrained by dose-dependent gastrointestinal complications, underscoring the urgent need for safer alternatives

The highest dose wins on paper, but only by 1.4 percentage points over 10 mg, while gastrointestinal side effects keep rising and discontinuation creeps up