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The commercial success of any weight loss therapeutic will depend heavily on patient acceptability and adherence, making oral, long-acting depot, and other non-injectable options critical pipeline priorities rather than nice-to-have features

Nature (2012) 490(7418):5560

With the national supply stabilizing, the FDA has established firm deadlines prohibiting further compounding of these medications

Many clinicians consider the combination safe when used appropriately

Rossing P, Caramori ML, Chan JCN et al (2022) KDIGO 2022 clinical practice guideline for diabetes management in chronic kidney disease