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These molecules influence: GLP-1 and PYY secretion insulin sensitivity mitochondrial energy pathways fat oxidation inflammation modulation appetite and metabolic rhythm Scientific Reference 3: Koh et al., Cell (2016) This high-impact review explains SCFAs mechanistic roles in host physiology: signalling through receptors (e.g., FFAR2/FFAR3), epigenetic modulation, immunegut interactions, and metabolic regulation

We observed a trend toward inadequate bowel preparation in patients undergoing colonoscopy who were on [GLP-1s], which raised concerns about practical consequences to these medication side effects, lead author Rebecca Yao, MD, MPH, an internal medicine resident at Mayo Clinic, in Rochester, Minn., told Gastroenterology & Endoscopy News

We expect the number included could be reduced in the near future

Temperature of the injection solution and injection speed can also influence discomfort levels

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