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Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation

Fragmentation with staphylococcal protease results in GIP1-3 and GIP4-42, fragmentation with enterokinase in GIP1-16 and GIP17-42

Neuroinflammation in Depression and Its Relation to GLP-1 The immune system in the CNS has been shown to regulate brain development, neurogenesis, mood, and behavior (Zheng et al., 2016

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Oral administration of PF-06882961 shows evidence of glucose-lowering in healthy human study participants PF-06882961 was selected as a candidate for clinical studies based on its in vitro and in vivo pharmacologic and disposition profile, including potent agonism of the GLP-1R, preclinical disposition attributes (e.g., low metabolic CL int in human hepatocytes), good safety margins versus the hERG channel (IC 50 = 4.3 M, Table S4) and broad panel screening (Table S8), and selectivity versus related class B GPCRs (Table S9)

Effect of linagliptin monotherapy on glycaemic control and markers of -cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial