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The expression of intestinal endocrine Lcells is regulated by several key receptors activated by short chain fatty acids (SCFAs), specific endogenous cannabinoids and bile acids, and the activation of these receptors increases the secretion of key intestinal peptides, such as GLP-1, GLP-2 and polypeptide YY (PYY) (de Vos et al., 2022)

Retatrutide does not yet have equivalent published body composition data

Cardiovascular outcome trials have shown reductions in cardiovascular events, including myocardial infarction and stroke [1][6]

[DOI] [PubMed] [Google Scholar] 512.Wang, X

Despite these challenges, the eGFR slope has emerged as a clinically meaningful outcome, with evidence indicating a robust renoprotective effect from the combined use of GLP1-RA and SGLT2i

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