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Growing evidence is building on the efficacy of GLP-1 RAs in NAFLD

Most patients report noticeable appetite reduction and initial weight changes within 2-4 weeks of starting GLP-1 therapy, though measurable fat loss typically accelerates after 8-12 weeks at therapeutic doses

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A five-month treatment with PEGylated exenatide (NLY01) was found to decrease the secretion of complement 1q (C1q), IL-1, and TNF- by primary mouse microglia, thereby limiting the conversion of astrocytes to a neurotoxic phenotype

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