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doi: 10.1210/en.2010-0068 194 ToniN.TengE

GLP-1s are not safe for people with a history of pancreatitis, certain thyroid cancers, MEN2 syndrome, severe kidney/liver disease, or during pregnancy/breastfeeding. How are GLP-1 medications taken

31 The overall TRIUMPH1 and TRIUMPH2 sample sizes provide at least 90% power to detect clinically meaningful weight reduction with retatrutide at 9 and 12 mg doses versus placebo on percent change in body weight, assuming each dose is analysed separately in parallel using a 2sample t test at a 2sided significance level of 0.0125

I shrugged this off as post-vacation blues

It belongs to a new class of molecules that activate three hormone receptors simultaneously: GLP-1, GIP and glucagon

Researchers continue to investigate its molecular characteristics, receptor interactions and biochemical behaviour using controlled laboratory techniques