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Image Credit: Love Employee / Shutterstock In a recent study published in the International Journal of Obesity , researchers assessed the effects of glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonists on weight and body composition in adults with overweight or obesity

The primary concern is the combined glucose-lowering effects of these drugs

The involvement of GLP-1 in PD can be simplified to the activation of the MAPK/extracellular signal-regulated kinase 1/2 (ERK) pathway, which has an important role in synaptic plasticity, and the PI3K/Akt pathway signaled by GLP-1 receptor stimulation and the subsequent increase in cAMP and PKA and PI3K activation [73]

This indicates that receptor signaling is tightly regulated by beta arrestins (39)