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In STEP-1 (Wilding et al., NEJM 2021), 68 weeks of once-weekly 2.4 mg semaglutide plus lifestyle intervention produced a mean body-weight reduction of about 15%, versus about 2.4% with placebo a large, clinically meaningful, well-replicated effect
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Diabetes Obes Metab 18:11761190 Pocai A, Carrington PE, Adams JR et al (2009) Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice
A major driver of this rise is the growing proportion of older adults in the population, as cancer risk increases significantly with increasing age
