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GLP-1 increases heart rate despite cervical vagotomy, autonomic ganglion blockade, and HCN channel blockade Next, we evaluated if the parasympathetic nervous system, or the combined autonomic nervous system, is involved in the GLP-1-induced increase in heart rate

In contrast, DPP-4 expressed within murine hepatocytes, adipocytes, or gut enterocytes is not required for physiological regulation of glucose tolerance and is dispensable for the glucoregulatory actions of DPP4i (20, 2325)

Microdose GLP-1 uses a much lower dose than standard treatments

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This is the phase where most people who are going to notice cardiovascular changes will notice them

2024;80(2):e546