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Do not use semaglutide if you or any of your family members have a history of MTC or if you have multiple endocrine neoplasia syndrome type 2 (MEN 2)
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What we know: The same total amount reaches your bloodstream - Clinical trial data confirmed equivalent overall absorption (AUC and Cmax) across all three sites Yet reported side effect rates differed substantially - Thigh showed roughly half the nausea rate of abdomen despite identical systemic exposure Possible explanations include differences in absorption rate (even if total absorption is equal), local tissue effects at the injection site, or simply statistical variation in a relatively small study
doi: 10.1210/jcem-24-10-1076 4 PerleyMJKipnisDM
And until recently, treatment options were extremely limited
