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Weight loss medications have changed the way people approach long-term weight management

The most common adverse effect is nausea

Lifestyle modification, bariatric surgery, or currently available medications may be better fits

These central receptors are complemented by the peripheral GLP-1 receptors located in the autonomic nervous system and nodose ganglion [39]

See electronic supplementary material (ESM) Table 1 for ICD, and ESM Table 2 for Anatomical Therapeutic Chemical (ATC) codes used for covariates and drugs included in the study

Results of a meta-analysis of clinical studies (21) indicate that treatment with GLP-1 receptor agonists is associated with A1C reductions from baseline of 0.42% for exenatide 5 g BID, 0.50% for lixisenatide 20 g once daily, 0.69% for albiglutide 30 mg QW, 0.71% for liraglutide 1.2 mg once daily, 0.75% for exenatide 10 g BID, 1.03% for liraglutide 1.8 mg once daily, and 1.09% for exenatide 2 mg QW and dulaglutide 1.5 mg QW versus placebo