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In rare cases, more serious side effects like pancreatitis, gallbladder issues, kidney problems, or vision changes may occur, especially in those with underlying conditions
The etiology of HIT is primarily related to genetic polymorphisms of DAO or HNMT, diseases associated with DAO or HNMT deficiency, dysbacteriosis, drugs that inhibit DAO activity, foods rich in histamine, foods that inhibit DAO, and foods that promote histamine release
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The loss of butyrate-producing bacteria initiates a devastating vicious cycle
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