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Most events were mild to moderate and occurred during dose escalation

Common side effects reported in clinical studies of semaglutide and tirzepatide include nausea, vomiting, diarrhea, constipation, and abdominal discomfort

Though much of the research on GLP-1R agonists has focused on the brain and pancreas, GLP-1R also is expressed elsewhere in the body and on EECs themselves (Grunddal et al., 2022)

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