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Importantly, the trial also demonstrated a reduction in all-cause mortality , making Victoza one of the first glucose-lowering medications shown to extend life expectancy in this population
There is evidence that when GLP-1 drugs are used responsibly alongside nutritional, activity and psychological support, they have a positive long-term impact on heart health, diabetes, breast & womb cancer and inflammatory diseases, beyond mere weight loss

These findings are a key reason GLP-1 therapies like Victoza are now recommended earlier in people with type 2 diabetes and established cardiovascular disease

J Am Pharm Assoc 2024

However, other studies show at least a trend for exendin4 to be subtly biased in favour of cAMP production over arrestin2 recruitment (Fremaux et al., 2019) or report relative potencies ratios in keeping with a degree of selectivity for cAMP production (Plisson et al., 2016)
Trends Endocrinol Metab 2019