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Some doctors are hesitant because the drugs' long-term safety for children during a critical phase of development is unknown, and the treatments may need to be used indefinitely
The size of the cohort precluded multivariate analyses, and there was the additional inconvenience that the follow-up period coincided with the advent of the COVID-19 crisis, which hampered proper data gathering and patient surveying
The 95% CIs were calculated manually when not reported in the original publications ( I 2 was calculated to quantify heterogeneity and inconsistency between studies
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