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Contemporary evidence has established a clear efficacy hierarchy among agents, with dual and triple receptor agonists demonstrating superior outcomes compared to traditional GLP-1 monotherapy (Table 4)

Then, the researchers administered exendin-4 via intrathecal injection to the experimental rats and observed a reduction in pain sensitivity, alleviation of neural inflammation, and suppression of inflammatory factors such as IL-1, TNF-, and iNOS

[PubMed ID: 19557413]

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Many plans already use some combination of eligibility criteria, documentation requirements, step therapy, or exclusions