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Research using data from U-M Healths primary care clinics shows that patients lose more weight, and sustain that loss, if they receive care guided by a provider trained in obesity medicine, and wraparound services, in addition to a prescription for a weight management medication

It is unclear whether the effects on weight are sufficient, by themselves, to enable fibrosis regression

doi: 10.1016/j.tim.2017.10.001

Abbreviations ARB: Angiotensin receptor blocker CKD: Chronic kidney disease CRP: C-reactive protein DKA: Diabetic ketoacidosis DKD: Diabetic kidney disease ERA: Endothelin receptor antagonist ESKD: End-stage kidney disease GIP: Glucose-dependent insulinotropic polypeptide GLP1: Glucagon-like peptide 1 GLP1-RA: Glucagon-like peptide 1 receptor agonist HF: Heart failure hsCRP: High-sensitivity C-reactive protein MACE: Major adverse cardiovascular events MRA: Mineralocorticoid receptor antagonist NO: Nitric oxide RAS: Reninangiotensin system sGC: Soluble guanylate cyclase SGLT2i: Sodiumglucose cotransporter-2 inhibitor(s) UACR: Urine albumin to creatinine ratio References Rossing P, Caramori ML, Chan JCH et al (2022) KDIGO 2022 clinical practice guideline for diabetes management in chronic kidney disease

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