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10 Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Al Sharqia, 44519, Egypt Correspondence: Kashif Rahim, School of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, Peoples Republic of China, Email [email protected] Saleh F Alqifari, Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, 71491, Saudi Arabia, Email [email protected] Abstract: DPP4 (Dipeptidyl-peptidase 4) a versatile protease, emerges as a prominent player in soluble and membrane-bound forms