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However, due to the nausea often associated with these drugs, initiating treatment at a lower dose and gradually increasing it can improve tolerability

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in: PubMed | Google Scholar | 1 Ted Rogers Centre for Heart Research, University of Toronto, Toronto, Ontario, Canada

The study found that semaglutide was associated with a higher incidence of gastrointestinal adverse events (62%) compared to placebo (42%), with a higher rate of cholelithiasis (4% versus 0%)