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In endothelial progenitor cells (EPC) derived from human peripheral blood mononuclear cells, high glucose conditions downregulate GLP-1-R and sirtuin 1 ( SIRT1 ) expression, leading to impaired cell functions and increased apoptosis via elevated acetylated p53 levels
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GLP-1 RAs may attenuate inflammatory response by down-regulating NF-kB signalling
Svensson CK, et al

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The key message for microdosing: Semaglutide delivers benefits across doses
