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Not only was energy intake during ad libitum lunch (primary endpoint) substantially lower with semaglutide vs placebo (approximately 35%), the same pattern also held true for subsequent ad libitum evening meal and evening snack box, demonstrating no compensatory effect due to a reduced lunch intake earlier in the day

Because oral semaglutide needs to be taken on an empty stomach to work properly, its not something you can take once youve already eaten or had anything to drink besides water

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Nanoscale 6 , 255262 (2014)

Moreover, the SELECT trial reported a 20% reduction in the incidence of major adverse cardiovascular events among 17,604 nondiabetic individuals who were overweight or obese and had a history of cardiovascular conditions

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