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European Union Recommended NAION Warnings In June 2025, the European Medicines Agency (EMA) recommended updating the labeling for semaglutide to list NAION as a very rare side effect, affecting up to 1 in 10,000 users

A 2023 review examining postmarket surveillance data found no clear pattern of birth defects among accidental exposures, though the sample size remains small

These are not theoretical concerns

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