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Per quanto riguarda lobesit, lAIFA ha recepito la valutazione positiva dellEMA approvando il farmaco anche per questa indicazione, ma per ora non ne prevista la rimborsabilit

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This corresponded to a risk difference of 0.3% (95% CI 0.4% to 0.1%) and a hazard ratio of 0.82 (95% CI 0.74 to 0.91) (Fig

It is also a substrate for enzymes like sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate gene expression, DNA repair, and cellular stress responses