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The STEP 1 extension study (Wilding et al., 2022) showed that participants regained a significant proportion of lost weight within one year of stopping semaglutide

Most studies used 12.5 mg or 25 mg daily as the therapeutic range, with 12.5 mg often providing meaningful testosterone elevation with fewer side effects and 25 mg reserved for men with a suboptimal initial response [3]

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Tirzepatide activates GLP-1 and GIPR receptors in the gut and brain, slowing gastric emptying and reducing appetite
doi: 10.1056/NEJMoa1411892 19 KolataGNolenS

PMC5550996 Kato M, et al
