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These include for example arterial plasma concentration as an input signal for compartmental or graphical modeling of radioligand/target receptor interactions such as Binding Potential (BP), a well understood and validated vascular contribution to the PET signal in tissue as well as the possibility of using brain regions without receptor expression as reference tissue
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[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Du Y., Su T., Song X., Gao J., Zou D., Zuo C., Xie W., Wang B., Zhang Z., Xu J., et al

Moreover, patients with NASH, particularly those with advanced metabolic risk factors like hypertension or type 2 diabetes, face a higher risk of adverse cardiovascular events and increased morbidity and mortality

Consequently, signals suggesting reduced cancer risk should be interpreted as compound-specific rather than a uniform class effect

Adding prandial GLP-1 receptor agonists to basal insulin: a promising option for type 2 diabetes therapy