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Due to sampling of baseline cohort characteristics and applied treatment effects in the PRIME T2D Model, as well as differences in mean HbA1c reductions between the oral semaglutide and liraglutide arms observed in PIONEER 4, treatment intensification occurred between years 116 in the oral semaglutide arm and years 115 in the liraglutide arm

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Daily liraglutide, with its 13-hour half-life, produces a much flatter steady-state smaller daily fluctuations in plasma drug concentration and, downstream, in glucose-insulin signalling