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Exercise can help, too

Individual variation in GLP-1 receptor density and sensitivity, baseline insulin resistance, metabolic rate, body composition, genetic factors affecting drug metabolism, concurrent medications or supplements, adherence to dietary and lifestyle recommendations, and starting weight all influence how quickly and dramatically you respond to semaglutide

Strong resistance to ongoing medication Need to honestly assess whether this is practical concern or psychological discomfort with accepting obesity as chronic condition

The decision to continue, reduce, or stop semaglutide should be made with your healthcare provider based on symptom severity, the benefit you are receiving from the medication, and alternative management options