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Step 1: Baseline Assessment Before starting therapy, patients undergo baseline laboratory testing including blood glucose, lipid profile, thyroid function, and liver and kidney function tests

Use different injection sites for different compounds

Theoretically, the pharmacological inhibition of SGLT2 could promote sodium excretion into urine

It works by mimicking the GLP-1 hormone, which helps regulate appetite, blood sugar levels, and digestion

Metformin also helps lower glucose production and improves insulin sensitivity, both of which aid in weight loss

Individuals who may be at greater risk include: Those with a pre-existing diagnosis of osteoarthritis, rheumatoid arthritis, or other inflammatory joint conditions Patients with obesity-related joint loading, particularly affecting the knees, hips, and lower back Older adults, in whom musculoskeletal complaints are more prevalent at baseline Individuals experiencing rapid weight loss, which may transiently alter joint mechanics and gait, particularly in the lower limbs this is a theoretical consideration based on general musculoskeletal principles rather than retatrutide-specific evidence Significant weight reduction one of retatrutide's primary therapeutic effects is generally associated with reduced mechanical load on weight-bearing joints , which may improve joint symptoms over time in individuals with obesity-related arthropathy