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this effect disappears when you stop taking the drug

Li, Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review

At the cellular level, butyrate acts as a powerful Histone Deacetylase (HDAC) inhibitor

Psychiatry 77 , 132S (2015)

It's like your skin builds a protective wall

For my differentiated thyroid cancer patients, I say, If you're obese, your metabolic health is going to cause more harm than an indolent thyroid cancer. There is research that shows that even if you slightly increase the thyroid cancer risk, you decrease the overall risk of all types of cancer if you reduce somebody's weight and get them to a metabolically healthier weight