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Moreover, because GLP-1R is expressed throughout the body, stimulation with a GLP-1R agonist or indirectly with a DPP-IV inhibitor can have a broad systemic effect on systemic metabolism, which, in turn, ameliorates peripheral and central insulin resistance in AD and MD (Athauda and Foltynie, 2016)

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US drug giant Eli Lilly also published an open letter saying it was "deeply concerned" about people selling medicines with phony or compounded versions of tirzepatide, the active ingredient behind its own Mounjaro and Zepbound drugs

The role of the gut microbiome in systemic inflammatory disease