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A retrospective study from Spain assessed FCP and clinical indices (partial Mayo for UC and HarveyBradshaw Index [HBI] for CD) in 16 patients with IBD prescribed GLP-1RA for obesity (five with semaglutide, 11 with liraglutide)

Microbiome-targeted therapies, such as fecal microbiota transplantation, antibiotics, bile acid modulators, and probiotics, demonstrate potential in combating intestinal dysbiosis, reducing bacterial populations responsible for endotoxin production, decreasing gut barrier permeability, restoring normal bile acid metabolism, improving liver chemistries, and eventually mitigating disease progression [36]

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GLP-1RAs can enhance neuronal DNA repair capacity through the base excision repair pathway (75)

However, the drugs manufacturer, Novo Nordisk, does not report it as a side effect

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