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Research applications include evaluating how complementary GIP and GLP-1 receptor activation modulates glucose-dependent insulin secretion , glucagon suppression , and energy balance in integrated biological systems

Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes

In patients with T2D in a phase 2 clinical trial, retatrutide (0.5 to 12 mg) significantly reduced body weight and HbA1c levels compared to placebo and 1.5 mg dulaglutide

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Beyond peptides, targeting molecules like aptamers (short DNA or RNA strands that bind specifically to targets), small molecules (designed to interact with disease-related receptors or enzymes), and carbohydrates (for targeting specific cell surface lectins or receptors) are also under investigation for their therapeutic potential [56,57,58,59,60]