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In the gnomAD database 15 , the rs10305420 T allele is most common in the European (40%) and Middle Eastern (38%) ancestry groups, followed by the Admixed American (28%), South Asian (20%) and East Asian (16%) ancestry groups, and least common in the African (7%) ancestry group

Mattano LA, Devidas M, Nachman JB, et al

Glia 55 , 10741084 (2007)

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Many patients notice appetite reduction within days, but measurable weight loss often appears by week 46
