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Sekizkardes H, Chung ST, Chacko S et al (2020) Free fatty acid processing diverges in human pathologic insulin resistance conditions

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Constipation means contents are backing up in the large intestine, which creates additional fermentation opportunity and can increase gas production throughout the entire digestive tract

With respect to GLP-1RAs, liraglutide and semaglutide have demonstrated a reduction in the risk of major adverse cardiovascular events (MACE) [16, 17], and, while yet not published, early reports for dulaglutide indicate CV benefits in patients with a wide range of CV risk [18]

Although the specific molecular mechanisms through which obesity promotes carcinogenesis remain not fully elucidated, epidemiological studies indicate that approximately 48% of malignant tumors can be attributed to obesity, and obesity serves as an independent risk factor for poor prognosis in cancer patients [54]

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