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Gastrointestinal side-effects can last a few weeks but usually resolve on their own unless a higher dose is taken.

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Expression of adenosine triphosphate (ATP)-sensitive potassium (K ATP ) channel subunits (sulphonylurea receptor 1 [SUR1] and inward-rectifier potassium channel 6.2 [Kir6.2]) has also been confirmed in K cells, and the addition of tolbutamide, a K ATP channel inhibitor, enhanced GIP release in primary mouse intestinal cultures [31]

Generic drugs require FDA approval by demonstrating bio-equivalence to a brand-name drug