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These effects are the leading reason patients stop therapy in real-world settings and are a predictable part of initiation

doi: 10.1021/acs.jmedchem.5b00726 61 Eli Lilly and Company

GIP (glucose-dependent insulinotropic polypeptide) has been identified in reproductive tissues, and GIP receptor activation may contribute to the hormonal benefits observed with tirzepatide

Semaglutide has been shown in animal studies to reduce ovarian inflammation in mice with PMOS, and early human research hints at similar anti-inflammatory effects

"We should take precaution with methodical ophthalmic care for diabetics on these drugs," Decotiis said
