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10.1016/j.molmed.2024.12.005 Trends Mol Med

Peripheral IR primarily involves reduced insulin-mediated glucose uptake by skeletal muscle and adipose tissue, driven by defects in the insulin receptor substrate and downstream signaling pathways such as phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), leading to diminished translocation of glucose transporter type 4 (SLC2A4/GLUT4) and glucose uptake [5]

The changes of renin plasma concentration after liraglutide and placebo were similar in both study groups

Insulin, Glucose, Insulin Resistance, and Pancreatic Cancer in Male Smokers

[DOI] [PubMed] [Google Scholar] 67.Centers for Disease Control and Prevention

The more accurate question is not is GLP-1 better than dieting, but rather: Is working with your biology more effective than fighting it
