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Users will almost certainly have to contend with side effects including nausea, vomiting, abdominal pain, constipation, and diarrhea

Semaglutide (Ozempic for diabetes, Wegovy for weight loss) represents the most effective pure GLP-1 agonist currently available

(This is quite common in the drug-development and launch process.) In the drugmaker-sponsored early trials, over 50% of participants lost more than 15% of their body weight

Nausea, diarrhea, vomiting, and constipation commonly occur within the first month of starting.[ref][ref] Note that for many people, gastrointestinal side effects seem to be dose-related

Placebo-controlled, randomized trial of the addition of once-weekly glucagon-like peptide-1 receptor agonist dulaglutide to titrated daily insulin glargine in patients with type 2 diabetes (AWARD-9) Diabetes, Obesity and Metabolism