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Weight regain : After stopping, many regain 60%-75% of lost weight within a year

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Although its exact mechanism of action is not fully understood, it is believed to work by suppressing appetite, preventing excess fat storage, reducing particular fat and cholesterol levels, and potentially influencing the brain's reward system to reduce binge eating

These results indicate that in addition to the significantly reduced labyrinth zone, maternal GLP-1R activation alters placental vascular structure

For years, GLP-1 medications like Wegovy required weekly injections a barrier that kept many eligible patients from starting treatment