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Pharmacy benefit managers report that brand-name semaglutide medications currently cost approximately $200 to $400 per month in Canada, with the variation attributed to: Prescribed dosage strength Regional pharmacy markup policies Provincial drug pricing regulations Wholesale distribution agreements Generic Competition Timeline Impact The current pricing landscape comes as Health Canada continues reviewing nine generic semaglutide applications following the January 2026 patent expiration

Figure 4 Discussion This meta-analysis is the first large sample study that was designed to assess the relationship between the use of GLP-1 receptor agonists and the occurrence of various thyroid disorders

37 In addition, Zhang et al (2020) found that a single nucleotide polymorphism (SNP) in GLP-1R, rs2295006, was negatively associated with lumbar and total hip BMD in postmenopausal women, and similar observations have been made more recently by others